Our results suggest that alpha and delta frequencies recorded acutely at the bedside predict left dorsal and ventral thalamic atrophy and functional recovery at 6 months postinjury. Specifically, we perform three analyses: (1) we assess the relationship between acute EEG spectral features and 6-month outcome (2) we assess the relationship between acute EEG spectral features and subcortical atrophy over the first 6 months post-injury and (3) we bring together EEG, MRI and other covariate variables in a multimodal analysis predicting 6-month outcome. The present study begins bridging this gap, adopting a multimodal approach combining EEG spectral analysis, 1 magnetic resonance (MR)-based measures of brain pathology 2, 3 and clinical outcome at 6 months. 1 Nonetheless, the exact relationship tying spontaneous electroencephalographic activity recorded acutely after traumatic brain injury (TBI), the unfolding of secondary brain damage processes in the subacute and chronic settings, 2, 3 and functional outcome remains poorly understood.
Because of its low cost and ease of use at the bedside, continuous electroencephalography (EEG) has become widely performed to measure electrical brain activity and to monitor neurological status of patients with severe brain injury.
